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Sebastian Cozma, Cristina Mihaela Ghiciuc, Lisandra Damian, Vittorio Pasquali, Angelo Saponaro, Elena Catalina Lupusoru, Francesca Romana Patacchioli, Lucia Corina Dima-Cozma
Distinct activation of the sympathetic adreno-medullar system and hypothalamus pituitary adrenal axis following the caloric vestibular test in healthy subjects
www.plosone.org
www.plosone.org
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6.0264 0 Td
(Denmark\))Tj
4.388 0 Td
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1.3833 0 Td
(60)Tj
1.1735 0 Td
(seconds)Tj
3.3675 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
2.075 0 Td
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1.1055 0 Td
(a)Tj
0.6576 0 Td
(patient)Tj
3.0047 0 Td
(with)Tj
1.9956 0 Td
(normal)Tj
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(horizontal)Tj
4.3426 0 Td
(semicircular)Tj
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(canal)Tj
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(two)Tj
1.7121 0 Td
(minutes)Tj
3.4639 0 Td
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1.0148 0 Td
(horizontal)Tj
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(nystagmus)Tj
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(the)Tj
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(direction)Tj
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1.0148 0 Td
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(stimulated)Tj
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(labyrinth.)Tj
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1.6044 0 Td
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(the)Tj
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1.3833 0 Td
(one)Tj
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(ear)Tj
1.4456 0 Td
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1.0261 0 Td
(avoid)Tj
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(any)Tj
1.6611 0 Td
(predictability)Tj
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(in)Tj
1.0375 0 Td
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(subjective)Tj
4.1613 0 Td
(vestibular)Tj
4.1102 0 Td
(sensation)Tj
3.9685 0 Td
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1.3889 0 Td
(the)Tj
1.4684 0 Td
(second)Tj
3.0103 0 Td
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1.6725 0 Td
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-34.35 -1.2983 Td
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2.296 0 Td
(that)Tj
1.7745 0 Td
(all)Tj
1.1508 0 Td
(volunteers)Tj
4.3824 0 Td
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2.0353 0 Td
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4.1159 0 Td
(any)Tj
1.6554 0 Td
(optic)Tj
2.2337 0 Td
(or)Tj
1.0998 0 Td
(audio-vestibular)Tj
6.7238 0 Td
(pathology,)Tj
-32.9327 -1.3039 Td
(and)Tj
1.7291 0 Td
(they)Tj
1.9219 0 Td
(had)Tj
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(never)Tj
2.4434 0 Td
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5.0343 0 Td
(the)Tj
1.4684 0 Td
(CVT)Tj
2.1883 0 Td
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2.965 0 Td
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2.2847 0 Td
(air)Tj
1.2926 0 Td
(irrigation)Tj
4.0195 0 Td
(and)Tj
1.7291 0 Td
(observation)Tj
4.8983 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-34.7015 -1.2982 Td
(nystagmus,)Tj
4.7168 0 Td
(the)Tj
1.4683 0 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(asked)Tj
2.4662 0 Td
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1.0204 0 Td
(rate)Tj
1.7518 0 Td
(the)Tj
1.4684 0 Td
(level)Tj
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(of)Tj
1.0148 0 Td
(their)Tj
2.1089 0 Td
(symptoms)Tj
4.3597 0 Td
(of)Tj
1.0148 0 Td
(dizziness)Tj
3.7984 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.6576 0 Td
(Likert)Tj
-34.6221 -1.2983 Td
(scale)Tj
2.1089 0 Td
(ranging)Tj
3.3165 0 Td
(from)Tj
2.2054 0 Td
(1)Tj
0.6973 0 Td
(to)Tj
1.0261 0 Td
(10,)Tj
1.3947 0 Td
(with)Tj
2.0012 0 Td
(1)Tj
0.6917 0 Td
(indicating)Tj
4.2689 0 Td
(no)Tj
1.2756 0 Td
(dizziness)Tj
3.8041 0 Td
(and)Tj
1.7291 0 Td
(10)Tj
1.1678 0 Td
(being)Tj
2.4322 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.211 0 Td
(intense)Tj
3.0897 0 Td
(sensa-)Tj
-34.8885 -1.3039 Td
(tion)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(dizziness)Tj
3.7984 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.0749 0 Td
(The)Tj
1.7858 0 Td
(duration)Tj
3.702 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(induced)Tj
3.4639 0 Td
(nystagmus)Tj
4.49 0 Td
(was)Tj
1.7008 0 Td
(measured)Tj
4.1102 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(audiologist)Tj
-33.1141 -1.2983 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(screen)Tj
2.7722 0 Td
(chronometer.)Tj
-4.3199 -1.2982 Td
(Ten)Tj
1.8085 0 Td
(minutes)Tj
3.4639 0 Td
(before)Tj
2.7382 0 Td
(the)Tj
1.4684 0 Td
(air)Tj
1.2925 0 Td
(CVT)Tj
2.1941 0 Td
(task,)Tj
2.0295 0 Td
(the)Tj
1.4741 0 Td
(subjects)Tj
3.3788 0 Td
(were)Tj
2.1203 0 Td
(attached)Tj
3.5887 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(12)Tj
1.1735 0 Td
(channel)Tj
3.3675 0 Td
(Holter)Tj
-32.9723 -1.2983 Td
(\(BTL-08)Tj
3.5886 0 Td
(CardioPoint-Holter,)Tj
8.3621 0 Td
(USA\))Tj
2.4548 0 Td
(for)Tj
1.389 0 Td
(continuous)Tj
4.7338 0 Td
(monitoring)Tj
4.8189 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(electrocardiogram)Tj
7.319 0 Td
(.)Tj
0.4422 0 Td
(The)Tj
-35.5915 -1.3039 Td
(SBP)Tj
1.8311 0 Td
(and)Tj
1.7348 0 Td
(DBP)Tj
2.092 0 Td
(were)Tj
2.1259 0 Td
(measured)Tj
4.1046 0 Td
(using)Tj
2.3924 0 Td
(a)Tj
0.652 0 Td
(semi-automatic)Tj
6.4516 0 Td
(sphygmomanometer)Tj
8.5152 0 Td
(\(M3;)Tj
2.1543 0 Td
(Omron,)Tj
3.4413 0 Td
(Mat-)Tj
-35.4952 -1.2983 Td
(susaka)Tj
2.8346 0 Td
(Co.)Tj
1.6157 0 Td
(LTD,)Tj
2.3301 0 Td
(Japan\).)Tj
3.05 0 Td
(MAP)Tj
2.3528 0 Td
(was)Tj
1.7008 0 Td
(calculated)Tj
4.2009 0 Td
(as)Tj
1.0148 0 Td
(\(2DBP)Tj
2.914 0 Td
(+)Tj
0.7993 0 Td
(SBP\)/3)Tj
2.9821 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
2.0749 0 Td
(Salivary)Tj
3.3562 0 Td
(samples)Tj
3.3846 0 Td
(were)Tj
-34.6108 -1.2983 Td
(collected)Tj
3.736 0 Td
(5)Tj
0.6973 0 Td
(minutes)Tj
3.4639 0 Td
(before)Tj
2.7439 0 Td
(the)Tj
1.4684 0 Td
(CVT)Tj
2.1883 0 Td
(task)Tj
1.8085 0 Td
(\(under)Tj
2.9594 0 Td
(the)Tj
1.4683 0 Td
(basal)Tj
2.2053 0 Td
(experimental)Tj
5.4595 0 Td
(condition\))Tj
4.4504 0 Td
(and)Tj
1.7348 0 Td
(1,)Tj
0.9184 0 Td
(4,)Tj
0.9241 0 Td
(7,)Tj
-36.2265 -1.3039 Td
(10,)Tj
1.3946 0 Td
(15,)Tj
1.3946 0 Td
(30,)Tj
1.4003 0 Td
(45)Tj
1.1679 0 Td
(and)Tj
1.7348 0 Td
(60)Tj
1.1679 0 Td
(min)Tj
1.8538 0 Td
(thereafter,)Tj
4.3086 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(time)Tj
2.0296 0 Td
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1.0148 0 Td
(the)Tj
1.4683 0 Td
(cardiovascular)Tj
6.0037 0 Td
(measurements.)Tj
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(all)Tj
1.1451 0 Td
(these)Tj
2.2564 0 Td
(experimental)Tj
5.4538 0 Td
(session)Tj
3.0501 0 Td
(time)Tj
2.0296 0 Td
(points,)Tj
2.9423 0 Td
(the)Tj
1.474 0 Td
(SBP)Tj
1.8312 0 Td
(and)Tj
1.7291 0 Td
(DBP)Tj
2.0976 0 Td
(were)Tj
2.1203 0 Td
(sequentially)Tj
4.9606 0 Td
(determined,)Tj
-31.0901 -1.2983 Td
(while)Tj
2.3697 0 Td
(the)Tj
1.4683 0 Td
(corresponding)Tj
6.0605 0 Td
(HR)Tj
1.6044 0 Td
(and)Tj
1.7348 0 Td
(R)Tj
0.839 0 Td
(to)Tj
1.0261 0 Td
(R)Tj
0.8391 0 Td
(wave)Tj
2.2167 0 Td
(interval)Tj
3.2655 0 Td
(were)Tj
2.1203 0 Td
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(the)Tj
1.4684 0 Td
(Holter)Tj
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(recording.)Tj
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(the)Tj
1.4684 0 Td
(end)Tj
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(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(CVT)Tj
2.1883 0 Td
(task)Tj
1.8142 0 Td
(session,)Tj
3.2711 0 Td
(PSS)Tj
1.7291 0 Td
(questionnaires)Tj
6.0662 0 Td
(were)Tj
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(administered)Tj
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(to)Tj
1.0261 0 Td
(measure)Tj
3.5773 0 Td
(the)Tj
-35.3591 -1.2983 Td
(self-perceived)Tj
5.7202 0 Td
(stress)Tj
2.3981 0 Td
(impact)Tj
2.9764 0 Td
(induced)Tj
3.4696 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(task,)Tj
2.0353 0 Td
(and)Tj
1.7291 0 Td
(individual)Tj
4.2916 0 Td
(scores)Tj
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(were)Tj
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(compared)Tj
4.2406 0 Td
(with)Tj
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(those)Tj
2.3357 0 Td
(measured)Tj
4.1102 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(enrollment)Tj
4.6545 0 Td
(day.)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 340.7244 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
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2.674 0 Td
(collection)Tj
4.2803 0 Td
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1.7906 0 Td
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(biomarker)Tj
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ET
Q
q
1 j
1 J
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BT
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1.7008 0 Td
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1.4683 0 Td
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(\(Sarstedt,)Tj
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(and)Tj
1.7348 0 Td
(hygienic)Tj
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2.4208 0 Td
(recovery)Tj
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2.2054 0 Td
(a)Tj
0.6576 0 Td
(polyester)Tj
3.8211 0 Td
(swab)Tj
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(centrifugation)Tj
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(3,000)Tj
2.3527 0 Td
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1.3832 0 Td
(15)Tj
1.1736 0 Td
(min)Tj
1.8538 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.6044 0 Td
(Salivary)Tj
3.3562 0 Td
(samples)Tj
3.3789 0 Td
(were)Tj
2.126 0 Td
(immediately)Tj
5.1987 0 Td
(frozen)Tj
2.7723 0 Td
(at)Tj
0.9524 0 Td
(20C)Tj
2.7439 0 Td
(until)Tj
2.109 0 Td
(the)Tj
1.4683 0 Td
(analysis.)Tj
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3.5546 0 Td
()Tj
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(-Amy)Tj
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(and)Tj
1.7291 0 Td
(cortisol)Tj
3.2031 0 Td
(assays)Tj
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(were)Tj
2.1203 0 Td
(performed,)Tj
4.6941 0 Td
(as)Tj
1.0148 0 Td
(previously)Tj
4.354 0 Td
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4.0478 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(],)Tj
1.6044 0 Td
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2.3868 0 Td
(commercially)Tj
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(available)Tj
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2.262 0 Td
(kits)Tj
1.6441 0 Td
(\(Diametra,)Tj
4.5694 0 Td
(Italy\).)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 242.9858 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
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2.2441 0 Td
(analysis)Tj
3.5055 0 Td
(and)Tj
1.7906 0 Td
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Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 225.9779 cm
BT
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(otherwise)Tj
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2.4434 0 Td
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2.3924 0 Td
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1.8312 0 Td
(11)Tj
1.1678 0 Td
(\(SxST.it,)Tj
3.6057 0 Td
(Italy\))Tj
2.3357 0 Td
(and)Tj
1.7291 0 Td
(Statistica)Tj
3.7757 0 Td
(6.0)Tj
1.4004 0 Td
(\(Statsoft)Tj
-32.5642 -1.2983 Td
(Inc,)Tj
1.7574 0 Td
(USA\))Tj
2.4548 0 Td
(software)Tj
3.5886 0 Td
(programs.)Tj
-6.6046 -1.3039 Td
(A)Tj
0.907 0 Td
(repeated)Tj
3.6397 0 Td
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3.9401 0 Td
(ANOVA)Tj
3.7644 0 Td
(test)Tj
1.6044 0 Td
(was)Tj
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1.0261 0 Td
(reveal)Tj
2.5739 0 Td
(the)Tj
1.4683 0 Td
(diurnal)Tj
3.1408 0 Td
(variation)Tj
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(of)Tj
1.0148 0 Td
(the)Tj
/F11 1 Tf
1.4684 0 Td
()Tj
/F7 1 Tf
(-)Tj
-35.7163 -1.2983 Td
(Amy)Tj
2.1769 0 Td
(and)Tj
1.7292 0 Td
(cortisol)Tj
3.2031 0 Td
(secretions)Tj
4.2066 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(effect)Tj
2.3641 0 Td
(of)Tj
1.0148 0 Td
(air)Tj
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(CVT)Tj
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(on)Tj
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(the)Tj
1.4684 0 Td
(salivary)Tj
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(cortisol)Tj
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(and)Tj
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1.7291 0 Td
()Tj
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(-Amy)Tj
3.1011 0 Td
(con-)Tj
-35.3931 -1.2982 Td
(centrations,)Tj
4.9265 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8199 0 Td
(as)Tj
1.0148 0 Td
(on)Tj
1.2755 0 Td
(SBP,)Tj
2.058 0 Td
(DBP,)Tj
2.3187 0 Td
(HR)Tj
1.6101 0 Td
(and)Tj
1.7348 0 Td
(RR,)Tj
1.6837 0 Td
(which)Tj
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(were)Tj
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(the)Tj
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(salivary)Tj
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(collections)Tj
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(during)Tj
2.9253 0 Td
(the)Tj
1.4627 0 Td
(air)Tj
1.2926 0 Td
(CVT)Tj
2.1826 0 Td
(task.)Tj
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1.9446 0 Td
(hoc)Tj
1.6724 0 Td
(analyses,)Tj
3.702 0 Td
(using)Tj
2.3868 0 Td
(Tukey's)Tj
3.3052 0 Td
(multiple)Tj
3.5659 0 Td
(compar-)Tj
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(ison)Tj
1.9048 0 Td
(test,)Tj
1.8255 0 Td
(were)Tj
2.1203 0 Td
(conducted)Tj
4.4277 0 Td
(to)Tj
1.0261 0 Td
(reveal)Tj
2.5739 0 Td
(subgroup)Tj
4.0025 0 Td
(differences.)Tj
4.7905 0 Td
(To)Tj
1.3379 0 Td
(evaluate)Tj
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